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Updated: Mar 24, 2026

Analyzing Murine Schwann Cell Development Along Growing Axons
Published on: November 21, 2012
Neuregulin/ErbB Signaling in Developmental Myelin Formation and Nerve Repair
Carmen Birchmeier1, David L H Bennett2
1Developmental Biology, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
Abstract:
Myelin is essential for rapid and accurate conduction of electrical impulses by axons in the central and peripheral nervous system (PNS). Myelin is formed in the early postnatal period, and developmental myelination in the PNS depends on axonal signals provided by Nrg1/ErbB receptors. In addition, Nrg1 is required for effective nerve repair and remyelination in adulthood. We discuss here similarities and differences in Nrg1/ErbB functions in developmental myelination and remyelination after nerve injury.
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