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Related Concept Videos

Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Related Experiment Video

Updated: Mar 24, 2026

Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics
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Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics

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Emerging Modeling Concepts and Solutions in Stem Cell Research.

Dmitri Papatsenko1, Ihor R Lemischka2

  • 1Department of Regenerative and Developmental Biology, Icahn School of Medicine at Mount Sinai, New York, USA; Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, USA.

Current Topics in Developmental Biology
|March 13, 2016
PubMed
Summary

Quantitative modeling in stem cell research is crucial for understanding differentiation and reprogramming. This review explores popular models and future insights from computational biology, enhancing biological system understanding.

Keywords:
Deterministic versus stochasticEmbryonic stem cellsHematopoietic stem cellsModularity, robustness, feedback controlMultiscale modelsPluripotency gene regulatory networksQuantitative modelsStem cell heterogeneity

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Last Updated: Mar 24, 2026

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Area of Science:

  • Computational Biology
  • Stem Cell Biology
  • Systems Biology

Background:

  • Modern biology, including stem cell research, increasingly relies on quantitative sciences like bioinformatics and biostatistics.
  • Understanding complex biological systems, such as stem cell differentiation and reprogramming, necessitates advanced biological models.

Purpose of the Study:

  • To review popular quantitative model types used in stem cell research.
  • To identify the features of stem cell behavior captured by these models.
  • To discuss future insights expected from computational modeling in stem cell research.

Main Methods:

  • Literature review of published quantitative models in stem cell research.
  • Analysis of model types and their applications in understanding stem cell behavior.
  • Exploration of emerging solutions and future directions in computational stem cell modeling.

Main Results:

  • Quantitative modeling in stem cell research, while challenging, offers modest results and predictions.
  • Popular model types capture specific features of stem cell differentiation and reprogramming.
  • The review identifies key trends and potential breakthroughs in the field.

Conclusions:

  • Computational modeling is essential for establishing causal links in stem cell differentiation and reprogramming.
  • Further development of quantitative models will provide deeper insights into complex biological systems.
  • The future of stem cell research will be significantly shaped by advances in computational modeling.