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Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

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IgG4-related nephropathy.

Giacomo Quattrocchio^1,2, Dario Roccatello^3,4,5

¹Nephrology and Dialysis Unit, Giovanni Bosco Hospital, Turin, Italy. g.quattrocchio@libero.it.

Journal of Nephrology

|March 15, 2016

Summary

Immunoglobulin G4-related disease (IgG4-RD) can affect the kidneys. An intensified immunosuppressive protocol showed good results for aggressive IgG4-related kidney disease and retroperitoneal fibrosis.

Keywords:

Glucocorticoids IgG4-related disease IgG4-related kidney disease Retroperitoneal fibrosis Rituximab Tubulointerstitial nephritis

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Assessment of Kidney Function in Mouse Models of Glomerular Disease

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

Area of Science:

Nephrology
Rheumatology
Immunology

Background:

Immunoglobulin G4-related disease (IgG4-RD) is a multi-organ fibroinflammatory condition.
Renal involvement in IgG4-RD includes tubulointerstitial nephritis (TIN) and membranous glomerulonephropathy.
Retroperitoneal fibrosis (RPF) is a common IgG4-related condition that can cause kidney obstruction.

Purpose of the Study:

To evaluate the efficacy of an intensified immunosuppressive protocol for aggressive IgG4-related kidney disease.
To assess treatment outcomes for IgG4-related retroperitoneal fibrosis.

Main Methods:

Utilized contrast-enhanced computerized tomography, magnetic resonance imaging, and PET/CT for diagnosis and monitoring.
Administered an intensified immunosuppressive protocol to patients with aggressive IgG4-related TIN and IgG4-related RPF.
Monitored patients for treatment response and adverse effects.

Main Results:

Successful treatment of three cases of aggressive IgG4-related TIN.
Successful treatment of two cases of IgG4-related RPF.
Achieved good therapeutic outcomes without severe adverse effects.

Conclusions:

An intensified immunosuppressive protocol is effective for aggressive IgG4-related kidney disease.
This protocol offers a viable treatment option for IgG4-related RPF.
Aggressive immunosuppression can be safely used in managing complex IgG4-RD cases.