Relationship between CD14-159C/T gene polymorphism and acute brucellosis risk

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Mehdi Moghadampour1, Ebrahim Eskandari-Nasab2, Fatemeh Shabani3

  • 1Department of Microbiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran; Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.

Asian Pacific Journal of Tropical Medicine
|March 15, 2016
PubMed
Abstract

Insights

The CD14-159C/T gene variant is linked to increased acute brucellosis risk in Iranians. The T allele and specific genotypes (CT, TT) were significantly more common in patients, suggesting a genetic predisposition.

Area of Science:

  • Genetics and Infectious Diseases
  • Immunogenetics
  • Molecular Epidemiology

Background:

  • Brucellosis is a significant zoonotic disease with varying susceptibility.
  • Genetic factors may influence an individual's risk of developing brucellosis.
  • The cluster of differentiation 14 (CD14) gene plays a role in immune response.

Purpose of the Study:

  • To examine the association between the CD14-159C/T (rs2569190) gene polymorphism and susceptibility to acute brucellosis.
  • To evaluate the role of specific CD14 genotypes and alleles in brucellosis risk within an Iranian population.

Main Methods:

  • Case-control study involving 153 Iranian brucellosis patients and 128 healthy controls.
  • Genotyping of the CD14-159C/T polymorphism was performed using the amplification refractory mutation system-polymerase chain reaction (ARMS-PCR).

Main Results:

  • The CD14-159 CT and TT genotypes were significantly associated with an increased risk of brucellosis (OR=1.993, P=0.03; OR=3.869, P=0.01, respectively).
  • The T allele was more prevalent in brucellosis patients (61%) compared to controls (45%), indicating it as a risk factor (OR=3.058, P=0.01).

Conclusions:

  • The CD14-159C/T gene polymorphism shows suggestive evidence of association with susceptibility to acute brucellosis in the Iranian population.
  • This genetic variant may contribute to the risk of developing brucellosis, warranting further investigation.
Keywords:
Acute brucellosisCluster of differentiation 14Single nucleotide polymorphism

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