Relationship between CD14-159C/T gene polymorphism and acute brucellosis risk

Area of Science:

• Genetics and Infectious Diseases
• Immunogenetics
• Molecular Epidemiology

Background:

• Brucellosis is a significant zoonotic disease with varying susceptibility.
• Genetic factors may influence an individual's risk of developing brucellosis.
• The cluster of differentiation 14 (CD14) gene plays a role in immune response.

Purpose of the Study:

• To examine the association between the CD14-159C/T (rs2569190) gene polymorphism and susceptibility to acute brucellosis.
• To evaluate the role of specific CD14 genotypes and alleles in brucellosis risk within an Iranian population.

Main Methods:

• Case-control study involving 153 Iranian brucellosis patients and 128 healthy controls.
• Genotyping of the CD14-159C/T polymorphism was performed using the amplification refractory mutation system-polymerase chain reaction (ARMS-PCR).

Main Results:

• The CD14-159 CT and TT genotypes were significantly associated with an increased risk of brucellosis (OR=1.993, P=0.03; OR=3.869, P=0.01, respectively).
• The T allele was more prevalent in brucellosis patients (61%) compared to controls (45%), indicating it as a risk factor (OR=3.058, P=0.01).

Conclusions:

• The CD14-159C/T gene polymorphism shows suggestive evidence of association with susceptibility to acute brucellosis in the Iranian population.
• This genetic variant may contribute to the risk of developing brucellosis, warranting further investigation.