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Migration of polymorphonuclear leukocytes in psoriasis.
1Department of Dermatology, University of Nijmegen, The Netherlands.
Skin Pharmacology : the Official Journal of the Skin Pharmacology Society
|January 1, 1989
Summary
Polymorphonuclear leukocytes (PMN) migration is impaired in psoriatic skin, impacting psoriasis development. Understanding this neutrophil dysfunction offers new therapeutic targets for psoriasis treatment.
Area of Science:
- Dermatology
- Immunology
- Cell Biology
Background:
- Psoriatic lesions feature intraepidermal polymorphonuclear leukocyte (PMN) infiltration, forming pustules.
- Pustular psoriasis is characterized by significant PMN accumulation.
- Recent research has advanced understanding of PMN migration regulation and inflammatory mediators.
Purpose of the Study:
- To review literature on PMN migration in normal and psoriatic skin.
- To elucidate the role of PMN in psoriasis pathogenesis.
- To explore PMN as a therapeutic target for antipsoriatic treatments.
Main Methods:
- Literature review focusing on transdermal and epidermal PMN migration.
- Analysis of PMN properties, inflammatory mediators, and their effects.
- Comparison of PMN migration in psoriatic versus normal skin.
Main Results:
- PMN migration is diminished in clinically uninvolved psoriatic skin and profoundly decreased in lesional skin.
- The mechanism of this reduced migration (tachyphylaxis) is not fully understood.
- Potential factors include inflammatory mediators, cytochrome P-450, endothelial function, and protease inhibitors.
Conclusions:
- PMN play a critical role in psoriasis pathogenesis.
- The impaired PMN migration in psoriatic skin presents a key area for therapeutic intervention.
- Further research into PMN dysfunction may lead to novel antipsoriatic strategies.