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Updated: Mar 24, 2026

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation
Published on: February 15, 2018
Structured promotion of breastmilk expression is associated with shortened hospitalisation for very preterm infants
David B Healy1, Ann-Marie Brennan2, Rebecca O'Donovan3
1Department of Paediatrics and Child Health, University College Cork, Cork, Ireland.
Aim:
This study assessed neonatal outcomes following implementation of a structured, practical approach for promotion of breastmilk expression in mothers of very preterm infants.
Methods:
A multidisciplinary team developed a protocol that focussed on the enhancement of expression of human milk by mothers of very preterm infants. A pre- and poststudy intervention was subsequently performed. The group of infants enrolled in this time period was compared to a pre-intervention group from 2010. Outcomes assessed included breastmilk expression, initiation of feeding, re-attainment of birthweight, attainment of full enteral feeding, the incidence of necrotising enterocolitis (NEC), sepsis and duration of hospitalisation.
Results:
In total, 82 infants (39,43) were included. While there was no statistically significant difference in earlier initiation of enteral feeding with EBM (median = 2 days) nor earlier achievement of fully enteral feeding (median = 12 days), birthweight was regained earlier in the postintervention cohort (mean = 10.42 days; p = 0.038) and there was a reduced length of stay (mean = 50 days; p = 0.021).
Conclusion:
A structured, focussed, multimodal approach to enhance breastmilk production has shown potential for producing positive end outcomes, particularly, a significant reduction in duration of hospitalisation.
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