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Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis
Kimberly Page1, Ali Mirzazadeh2, Thomas M Rice2
1Division of Epidemiology, Biostatistics and Preventive Medicine , University of New Mexico Health Sciences Center , Albuquerque, New Mexico.
Abstract:
Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus infection. This association potentially explains the higher spontaneous clearance observed in some patients with symptomatic disease.
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