Related Experiment Video
Updated: Mar 24, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Intravenous antimicrobial therapy in the hospital-at-home setting: data from the Spanish Outpatient Parenteral
Manuel Mirón-Rubio1, Víctor González-Ramallo2, Oriol Estrada-Cuxart3
1Hospital Universitario de Torrejón, Torrejón de Ardoz, Madrid, Spain.
Aim:
To evaluate outpatient parenteral antimicrobial therapy (OPAT) in the hospital-at-home (HaH) model, using data from a Spanish registry.
Patients & Methods:
We describe episodes/characteristics of patients receiving OPAT.
Results:
Four thousand and five patients were included (mean age 66.2 years), generating 4416 HaH episodes, 4474 infections and 5088 antibiotic treatments. Most patients were from the hospital admission ward and emergency department. Respiratory, urinary and intra-abdominal infections predominated (72%). Forty-six different antimicrobials were used, including combinations of ≥ 2 drugs (20.7%). Most HaH episodes had a successful outcome (91%).
Conclusion:
Our findings are similar to those obtained previously although our study case profiles differ, suggesting that disease processes of greater severity and complexity can be treated using this healthcare model, without compromising patient safety.
Related Concept Videos
Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Acute Pyelonephritis II: Diagnostic Studies and Management
Urinary Tract Infection IV: Nursing Management
Endocarditis IV: Nursing Management
Venous Thrombosis III: Interprofessional Care
Automated Microbial Diagnostics

