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Primary Cutaneous Aspergillosis in a Preterm Infant
Marie Antoinette Frick1, Hector Boix, Fátima Camba Longueira
1From the *Pediatric Infectious Diseases and Immunodeficiencies Unit, †Neonatology Department, ‡Microbiology Department, and §Preventive Medicine and Epidemiology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
The Pediatric Infectious Disease Journal
|March 15, 2016
Summary
Primary cutaneous aspergillosis is rare in premature infants. This case highlights severe voriconazole toxicity in a preterm infant, emphasizing the need for cautious use of this antifungal agent.
Area of Science:
- Neonatal Medicine
- Mycology
- Dermatology
Background:
- Primary cutaneous aspergillosis is a rare fungal infection affecting premature infants.
- Treatment typically involves combined medical and surgical approaches.
- Liposomal amphotericin B is the recommended first-line antifungal therapy.
Observation:
- This report details a case of severe primary cutaneous aspergillosis in a preterm infant.
- Voriconazole was used as a salvage regimen due to the severity of the infection.
- The patient experienced severe toxicity during voriconazole treatment.
Findings:
- The pharmacodynamics of voriconazole are not well-established in the preterm infant population.
- Severe adverse events were observed in this preterm patient receiving voriconazole.
- This case underscores potential risks associated with voriconazole in neonates.
Implications:
- Clinicians should exercise caution when considering voriconazole for preterm infants with cutaneous aspergillosis.
- Further research is needed to understand voriconazole pharmacodynamics and safety in neonates.
- Alternative or modified antifungal strategies may be necessary for this vulnerable population.
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