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Updated: Mar 24, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
Published on: October 7, 2025
Martin Köbel1, Kurosh Rahimi, Peter F Rambau
1Calgary Laboratory Services/Alberta Health Services (M.K., P.F.R., C.N., S.L.), Department of Pathology and Laboratory Medicine, Foothill Medical Center, University of Calgary, Calgary Department of Laboratory Medicine and Pathology (X.L., C.A.E., C.-H.L.), University of Alberta, Edmonton, AB Centre de recherche du (K.R., C.L.P., L.M., M.d.L., D.P., A.-M.M.M.), Centre hospitalier de l'Université de Montréal (CRCHUM) Departments of Pathology (K.R.) Obstetric-Gynecology (D.P.) Medicine (A.-M.M.M.), Université de Montréal Institut du cancer de Montréal (C.L.P., L.M., M.d.L., D.P., A.-M.M.M.), Montreal, QC Department of Pathology (S.L., D.H., C.B.G.), University of British Columbia, Vancouver, BC Department of Cellular and Molecular Medicine (B.V.), University of Ottawa, ON, Canada Department of Pathology (P.F.R.), Catholic University of Health and Allied Sciences-Bugando, Mwanza, Tanzania Department of Health Sciences Research (E.L.G.), Mayo Clinic, Rochester, Minnesota Department of Preventive Medicine (S.J.R.), Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California Department of Pathology and Cytology (J.W.C.), Institution for Oncology-Pathology, Karolinska University Hospital, Stockholm, Sweden Department of Public Health Sciences (L.E.K.), College of Medicine, Medical University of South Carolina Hollings Cancer Center (L.E.K.), Medical University of South Carolina, Charleston, South Carolina.
This study developed accurate immunohistochemical (IHC) algorithms to reclassify ovarian carcinoma histotypes, improving diagnostic accuracy for research and clinical practice.
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