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Crizotinib-induced toxicity in an experimental rat model
Ozge Gumusay1, Guldal Esendagli-Yilmaz2, Aytug Uner3
1Division of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Gaziosmanpasa University, 60250, Tokat, Turkey. ozgebostankolu@hotmail.com.
Aim:
The aim of the present study was to evaluate the effect of crizotinib on visceral organs in an experimental rat model.
Methods:
Eighteen Wistar albino rats were divided into three groups: experimental toxicity was induced with crizotinib (10 mg/kg) administered for 28 days (Group 1), 42 days (Group 2) orally by gavage. Control group received only distilled water. Rats in Group 1 and Group 2 were sacrificed after the collection of blood and tissue samples on the 28th and 42nd days, respectively.
Results:
Subjects in Group 1 and Group 2 had abnormal histology mainly in lung and liver. There were intraalveolar hemorrhage in lungs; mild portal inflammation, perivenular focal and confluent necrosis in liver; inflammatory reaction in renal pelvis and periureteral areas, and focal pancreatitis in pancreas.
Conclusion:
This study is the first to evaluate the histopathological features of toxicity of crizotinib in a rat model.
