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Contacting authors to retrieve individual patient data: study protocol for a randomized controlled trial.

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Financial incentives may improve the retrieval of individual patient data (IPD) for meta-analyses. This study will determine if offering incentives to researchers increases IPD submission rates for systematic reviews.

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Area of Science:

  • Medical research methodology
  • Evidence synthesis
  • Data management in clinical trials

Background:

  • Individual patient data (IPD) meta-analysis is the gold standard for subgroup analysis but obtaining IPD is challenging.
  • Current methods for IPD retrieval are time-consuming and require direct researcher contact.
  • No studies have evaluated strategies to optimize IPD retrieval from trial researchers.

Purpose of the Study:

  • To examine the impact of financial incentives on the retrieval of individual patient data (IPD) from researchers.
  • To assess whether incentives improve response rates and data completeness for meta-analyses.
  • To identify factors influencing IPD submission and data sharing time.

Main Methods:

  • Updated systematic reviews for type 1 diabetes and Alzheimer's dementia.
  • Randomized controlled trials (RCTs) eligible for reviews were identified.
  • Authors were randomized to receive a financial incentive for IPD submission or not; response rates and data sharing time were compared.

Main Results:

  • The study will determine if financial incentives affect response rates for IPD requests.
  • Secondary outcomes include time to dataset return and data completeness.
  • Logistic and Cox regression analyses will explore factors influencing IPD provision.

Conclusions:

  • This study will provide evidence on the effectiveness of financial incentives for IPD retrieval.
  • Findings will be disseminated via open access publication and conference presentations.
  • Results aim to optimize IPD meta-analysis processes.