Related Experiment Video
Updated: Mar 24, 2026
09:09
Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock
Published on: November 3, 2023
1.6K
Coupled plasma filtration adsorption improves hemodynamics in septic shock
Matteo Franchi1, Marilù Giacalone1, Ippolito Traupe1
1University of Pisa, 56126 Pisa, Italy.
Journal of Critical Care
|March 16, 2016
Summary
Coupled plasma filtration adsorption (CPFA) significantly improved hemodynamic stability in septic shock patients. This treatment enhanced mean arterial pressure and renal function, aiding in the amelioration of organ failure.
Area of Science:
- Critical Care Medicine
- Immunology
- Nephrology
Background:
- Septic shock is a life-threatening condition characterized by immune dysregulation, leading to hemodynamic instability and multiple organ failure.
- Effective management strategies for septic shock are crucial to improve patient outcomes.
Purpose of the Study:
- To evaluate the impact of coupled plasma filtration adsorption (CPFA) on the hemodynamic profile of patients experiencing septic shock.
- To assess the efficacy of CPFA in mitigating organ dysfunction associated with septic shock.
Main Methods:
- A retrospective analysis of 21 adult patients diagnosed with septic shock in an intensive care unit setting.
- Comparison of hemodynamic parameters and laboratory values before and after CPFA treatment, with a maximum of 5 treatment cycles.
Main Results:
- CPFA treatment led to a significant increase in mean arterial pressure (P < .001).
- A significant reduction in the requirement for vasoactive/inotropic support was observed (P = .007).
- CPFA demonstrated renal improvement and normalized leukocyte counts in patients with leukocytosis or leucopenia.
Conclusions:
- Coupled plasma filtration adsorption is an effective therapeutic intervention for improving hemodynamic parameters in septic shock.
- CPFA treatment contributes to the amelioration of organ failure in patients with septic shock.
Related Concept Videos
01:25Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration
327
Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
327
01:26Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy
336
Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in...
336
01:30Continuous Renal Replacement Therapy
1.8K
Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
1.8K
01:20Acute Kidney Injury V: Interprofessional Care
453
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
453
01:29Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
638
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
638
01:25Hemodialysis I: Introduction
3.0K
Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
3.0K