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Epigenetic regulators: Polycomb-miRNA circuits in cancer
1Department of Biochemistry Biophysics and General Pathology, Second University of Naples, Naples, Italy.
Biochimica Et Biophysica Acta
|March 16, 2016
Summary
Polycomb group (PcG) proteins regulate genes epigenetically. Aberrations in PcG-microRNA networks are linked to cancer, but targeting PcG proteins shows therapeutic promise for various cancers.
Area of Science:
- Epigenetics
- Molecular Biology
- Oncology
Background:
- Polycomb group (PcG) proteins are key epigenetic modifiers controlling gene expression.
- Dysregulation of PcG-microRNA interplay is implicated in various cancers with poor prognosis.
Purpose of the Study:
- To review critical PcG-microRNA molecular networks in cancer.
- To highlight the therapeutic potential of targeting PcG proteins.
Main Methods:
- Literature review of PcG-miRNA interactions in cancer.
- Discussion of compounds targeting PcG proteins in clinical trials.
Main Results:
- PcG-miRNA networks bridge chromatin remodeling and gene regulation.
- Compounds targeting PcG proteins are in clinical trials for solid tumors, multiple myeloma, and B lymphomas.
Conclusions:
- PcG-miRNA networks are crucial in cancer development.
- Targeting PcG proteins represents a promising therapeutic strategy for cancer treatment.
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