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Determinants of minimal elevation in high-sensitivity cardiac troponin T in the general population

Jonathan Rubin1, Kunihiro Matsushita2, Mariana Lazo2

  • 1Department of Medicine, Columbia University Medical Center, New York, NY, USA; Department of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA.

Clinical Biochemistry
|March 16, 2016
PubMed

Insights

Cardiovascular risk factors like hypertension and diabetes are linked to detectable cardiac troponin-T (hs-cTnT) in adults without heart disease. Even individuals with ideal cardiovascular health showed detectable hs-cTnT levels.

Area of Science:

  • Cardiology
  • Biomarkers
  • Public Health

Background:

  • Cardiac troponin-T (hs-cTnT) is a biomarker for cardiac injury.
  • Detecting hs-cTnT in individuals without cardiovascular disease (CVD) is not well understood.
  • Understanding associations between CVD risk factors and hs-cTnT is crucial for early detection.

Purpose of the Study:

  • To investigate the relationship between cardiovascular risk factors and detectable hs-cTnT.
  • To analyze these associations in a population free of diagnosed CVD.
  • To utilize a highly sensitive assay (hs-cTnT) for precise detection.

Main Methods:

  • Cross-sectional study of 9593 participants from the Atherosclerosis Risk in Communities (ARIC) Study.
  • Multivariable logistic regression used to assess associations.
  • Defined detectable hs-cTnT as ≥3.0 to 13.9 ng/L and elevated as ≥14.0 ng/L.

Main Results:

  • hs-cTnT was detectable in 59% and elevated in 7% of participants.
  • Detectable hs-cTnT was more common in males, Black individuals, and those with diabetes or hypertension.
  • Older age, higher BMI, and lower kidney function were also associated with detectable hs-cTnT.

Conclusions:

  • Detectable hs-cTnT is prevalent in adults without CVD, including those with ideal cardiovascular health.
  • Traditional CVD risk factors, notably sex, age, race, hypertension, and diabetes, are robustly associated with detectable hs-cTnT.
  • These findings highlight the importance of hs-cTnT as a potential indicator even in asymptomatic individuals.
Abstract

Keywords:
Cardiovascular diseaseEpidemiologyRisk factorsTroponin

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