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Updated: Mar 24, 2026

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
Published on: August 23, 2024
Monocyte cell membrane-derived nanoghosts for targeted cancer therapy
S Krishnamurthy1, M K Gnanasammandhan2, C Xie1
1School of Chemical and Biomedical Engineering and Lee Kong Chian School of Medicine, Nanyang Technological University, Block N1.3, #B4-10, 70 Nanyang Drive, Singapore 637457. julianachan@ntu.edu.sg.
Abstract:
Core-shell type 'nanoghosts' were synthesized with a drug-loaded biodegradable PLGA core and a monocyte cell membrane-derived shell. The nanoghosts were monodisperse with an average size <200 nm, and showed good serum stability for 120 h. Doxorubicin-loaded nanoghosts showed greater cellular uptake and cytotoxicity compared to non-coated nanoparticle controls in metastatic MCF-7 breast cancer cell lines.

