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Related Concept Videos

Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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Reticular Dermis01:15

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
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[Morphea or juvenile localised scleroderma: Case report].

Alexis Strickler1, Silvanna Gallo1, Pedro Jaramillo2

  • 1Departamento de Pediatría, Universidad San Sebastián sede Puerto Montt, Puerto Montt, Chile.

Revista Chilena De Pediatria
|March 16, 2016
PubMed
Summary

Juvenile localized scleroderma (JLS) is a chronic autoimmune condition. This case highlights delayed diagnosis but positive treatment response in an 8-year-old girl with linear and pansclerotic JLS.

Keywords:
AutoimmuneAutoinmuneEsclerodermia localizada juvenilJuvenile localised sclerodermaMorfeaMorphea

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Area of Science:

  • Dermatology
  • Rheumatology
  • Pediatrics

Background:

  • Juvenile localized scleroderma (JLS) is a chronic, autoimmune connective tissue disease affecting skin and underlying tissues.
  • Morphea is the common term for JLS, characterized by inflammation and slow progression.
  • The exact cause of JLS remains unknown.

Observation:

  • An 8-year-old girl presented with a two-year history of indurated, hypopigmented plaques on her right upper extremity.
  • She also had hyperpigmented plaques with thinned, whitish skin on her right lower extremity, along with leg and ankle swelling.
  • Clinical features and histological findings were consistent with linear and pansclerotic JLS.

Findings:

  • The patient was diagnosed with linear and pansclerotic эпидермально-локализованный JLS (ELJ).
  • There was a significant two-year delay in diagnosis.
  • Treatment included immunosuppressive therapy, physiotherapy, and occupational therapy, leading to a positive response.

Implications:

  • Early diagnosis and prompt treatment are crucial for managing JLS.
  • This case underscores the importance of recognizing JLS symptoms for timely intervention.
  • Effective management strategies involve a multidisciplinary approach including medical and rehabilitative therapies.