Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

997
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
997
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

2.4K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
2.4K
Human Genetics01:28

Human Genetics

1.8K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.8K
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

810
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
810
Schizophrenia01:17

Schizophrenia

1.5K
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
1.5K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

38.6K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
38.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oxytocin and vasopressin genes are significantly associated with schizophrenia in a large Arab-Israeli pedigree - CORRIGENDUM.

The international journal of neuropsychopharmacology·2019
Same author

Differential effects of chronic stress in young-adult and old female mice: cognitive-behavioral manifestations and neurobiological correlates.

Molecular psychiatry·2017
Same author

Alterations in the expression of a neurodevelopmental gene exert long-lasting effects on cognitive-emotional phenotypes and functional brain networks: translational evidence from the stress-resilient Ahi1 knockout mouse.

Molecular psychiatry·2016
Same author

Evidence of CNIH3 involvement in opioid dependence.

Molecular psychiatry·2015
Same author

Treatment of unipolar major depression: Algorithms for pharmacotherapy.

International journal of psychiatry in clinical practice·2014
Same author

Amygdalar disconnectivity could underlie stress resilience in the Ahi1 knockout mouse: conclusions from a resting-state functional MRI study.

Molecular psychiatry·2014

Related Experiment Video

Updated: Mar 24, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

26.6K

Searching for genes in Schizophrenia.

D B Wildenauer1, S G Schwab1, W Maier1

  • 1Molecular Genetics Laboratory,Dept. of Psychiatry,University of Bonn.

Acta Neuropsychiatrica
|March 16, 2016
PubMed
Summary

Genetic factors significantly contribute to schizophrenia risk, as evidenced by twin studies showing higher concordance in identical twins. Uncovering genetic variations is key to developing targeted schizophrenia treatments.

More Related Videos

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells
08:04

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells

Published on: November 19, 2020

7.1K
Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

4.8K

Related Experiment Videos

Last Updated: Mar 24, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

26.6K
Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells
08:04

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells

Published on: November 19, 2020

7.1K
Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

4.8K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Schizophrenia etiology research has yielded fragmented results at the phenotypic level.
  • Genetic factors have been consistently implicated in schizophrenia since early studies.
  • Family, twin, and adoption studies provide evidence for a genetic contribution.

Purpose of the Study:

  • To review the evidence for genetic factors in schizophrenia.
  • To highlight the potential of genetic research for understanding neuropathology and developing treatments.

Main Methods:

  • Review of family, twin, and adoption studies.
  • Analysis of concordance rates in identical and non-identical twins.
  • Consideration of advances in genetic analysis and the Human Genome Project.

Main Results:

  • Identical twins have a 48% risk of schizophrenia if one is affected, compared to 17% for non-identical twins.
  • Schizophrenia shares genetic complexity with other disorders like diabetes, hypertension, and asthma.

Conclusions:

  • Genetic factors play a substantial role in schizophrenia.
  • Advances in genomics are expected to elucidate molecular causes and neuropathology.
  • Identifying genetic variations will facilitate the development of targeted schizophrenia therapies.