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Patient centric formulations for paediatrics and geriatrics: Similarities and differences
Sara M Hanning1, Felipe L Lopez1, Ian C K Wong1
1UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom.
International Journal of Pharmaceutics
|March 16, 2016
Summary
Developing effective medicine formulations for pediatric and geriatric patients requires special consideration due to unique challenges like polypharmacy in older adults and taste in children. Advanced pharmaceutical technologies offer new solutions for these diverse populations.
Area of Science:
- Pharmaceutical Science
- Drug Delivery
- Patient-Centric Formulations
Background:
- Paediatric and geriatric populations are highly heterogeneous, necessitating tailored dosage form development.
- Key challenges include polypharmacy in the elderly and palatability issues in children.
Purpose of the Study:
- To discuss the similarities, differences, and considerations in developing appropriate medicine formulations for paediatric and geriatric patients.
- To explore how pharmaceutical technology advancements can address formulation challenges in these specific age groups.
Main Methods:
- Literature review and discussion of formulation strategies.
- Analysis of pharmaceutical technologies such as fixed-dose combinations (FDCs), multi-particulates, and orodispersible dosage forms.
Main Results:
- Identified polypharmacy and taste as significant barriers in geriatric and paediatric populations, respectively.
- Highlighted the potential of advanced pharmaceutical technologies to create novel and appropriate formulations.
- Emphasized the need for collaboration between formulation scientists, patients, carers, and clinicians.
Conclusions:
- Tailored pharmaceutical formulations are crucial for effective treatment in paediatric and geriatric patients.
- Technological advancements offer promising solutions, but patient-centered development is essential for successful implementation.
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