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Chordin-Like 1 Suppresses Bone Morphogenetic Protein 4-Induced Breast Cancer Cell Migration and Invasion

Chanèle Cyr-Depauw1, Jason J Northey1, Sébastien Tabariès2

  • 1Goodman Cancer Research Centre, McGill University, Montréal, Québec, Canada Department of Biochemistry, McGill University, Montréal, Québec, Canada.

Molecular and Cellular Biology
|March 16, 2016
PubMed

Insights

Chordin-like 1 (Chrdl1) inhibits bone morphogenetic protein (BMP) signaling, reducing breast cancer cell migration and invasion. High Chrdl1 expression correlates with better patient outcomes, suggesting a protective role in breast cancer progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • ShcA mediates ErbB2 and transforming growth factor β (TGF-β) effects on breast cancer metastasis.
  • Bone morphogenetic proteins (BMPs) are increasingly recognized for their role in breast cancer aggressiveness.

Purpose of the Study:

  • To investigate the role of chordin-like 1 (Chrdl1) as a BMP antagonist in breast cancer.
  • To determine if Chrdl1 can inhibit BMP-induced breast cancer cell migration and invasion.

Main Methods:

  • Upregulation of Chrdl1 in breast cancer cells after TGF-β stimulation.
  • Treatment of breast cancer cells with Chrdl1-containing medium or recombinant Chrdl1.
  • Assessment of BMP4-induced signaling, cell migration, invasion, and matrix metalloproteinase (MMP) activity.
  • Analysis of Chrdl1 expression in patient data.

Main Results:

  • Chrdl1 suppresses BMP4-induced signaling in breast cancer cells.
  • Chrdl1 effectively blocks BMP4-stimulated breast cancer cell migration and invasion.
  • BMP4-induced matrix degradation via MMP2 and MMP9 is antagonized by Chrdl1.
  • Higher Chrdl1 expression in patients is linked to improved clinical outcomes.

Conclusions:

  • Chrdl1 functions as a negative regulator of malignant breast cancer phenotypes.
  • Chrdl1 inhibits breast cancer progression by antagonizing BMP signaling pathways.

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