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Related Experiment Video

Updated: Mar 24, 2026

Rapid Magnetic-microbead Method for Efficient Purification of Low-density Neutrophils
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Published on: November 11, 2025

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Immunoreceptors on neutrophils.

Dieke J van Rees1, Katka Szilagyi1, Taco W Kuijpers2

  • 1Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Seminars in Immunology
|March 16, 2016
PubMed
Summary

Neutrophil immunoreceptors tightly control immune responses, balancing host defense and preventing harmful activities in conditions like autoimmunity and cancer. These receptors are key targets for therapeutic interventions.

Keywords:
ITAMITIMImmunoreceptorsNeutrophilsSHIPSHPSyk

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Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Signaling

Background:

  • Neutrophils are crucial for host defense against pathogens.
  • Dysregulated neutrophil activity contributes to diseases like autoimmunity and cancer.
  • Neutrophil functions are regulated by plasma membrane immunoreceptors.

Purpose of the Study:

  • To review the functions and signaling of neutrophil immunoreceptors.
  • To highlight the role of immunoreceptors in neutrophil effector mechanisms.
  • To discuss the implications of immunoreceptor signaling in health and disease.

Main Methods:

  • Review of existing literature on neutrophil immunoreceptors.
  • Analysis of signaling pathways, including ITAM and ITIM motifs.
  • Examination of ligand recognition by immunoreceptors.

Main Results:

  • Neutrophil immunoreceptors recognize diverse extracellular ligands.
  • Signaling commonly involves conserved ITAM/ITIM motifs and tyrosine phosphorylation.
  • These pathways enable homeostatic regulation of neutrophil functions.
  • Pathogens have evolved to manipulate or be recognized by these receptors.

Conclusions:

  • Neutrophil immunoreceptors are essential for tightly controlled immune responses.
  • Understanding these receptors offers insights into host-pathogen interactions.
  • Neutrophil immunoreceptor signaling represents a promising therapeutic target.