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Updated: Mar 24, 2026
A Murine Orthotopic Bladder Tumor Model and Tumor Detection System
Published on: January 12, 2017
Expression of γ-Synuclein in Bladder Carcinoma: A Possible Marker for Prognosis
Zhigang Chen1, Zhigang Ji1, Qinghai Wang1
1Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China.
Aim:
To investigate if γ-synuclein (SNCG) could be used as a bladder cancer (BC) marker to predict prognosis of BC.
Patients And Methods:
Medical records of 140 patients with BC (January, 2006 to December, 2009) were retrospectively reviewed. SNCG expression level was examined by immunohistological staining. The patients' survival rate was calculated by the Kaplan-Meier method. Cox proportional regression model was used to identify independent predictors for BC.
Results:
Overexpression of SNCG was detected in BC tissues and the expression level of SNCG strongly positively correlated with BC recurrence. However, no correlation was found between SNCG level and tumor stage or survival rate.
Conclusion:
SNCG is a good marker to predict recurrence of BC, but not a reliable marker for staging or prediction of survival rate.
