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Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

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Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
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Related Experiment Video

Updated: Mar 24, 2026

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
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A brief yoga intervention implemented during chemotherapy: A randomized controlled pilot study.

Stephanie J Sohl, Suzanne C Danhauer, Gurjeet S Birdee

    Complementary Therapies in Medicine
    |March 16, 2016
    PubMed
    Summary

    This study found that a brief yoga intervention is feasible for patients with colorectal cancer undergoing chemotherapy. Yoga Skills Training (YST) showed high adherence and retention, supporting future research on its benefits.

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    Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
    05:56

    Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting

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    Area of Science:

    • Oncology
    • Integrative Medicine
    • Clinical Trials

    Background:

    • Fatigue and sleep disturbance significantly impact quality of life for cancer patients during chemotherapy.
    • Yoga interventions show promise in mitigating treatment-related symptoms.

    Purpose of the Study:

    • To assess the feasibility of a randomized controlled trial for a brief yoga intervention in colorectal cancer patients receiving chemotherapy.
    • To inform future research by collecting preliminary data on outcomes and challenges.

    Main Methods:

    • Adult patients with colorectal cancer were randomized to Yoga Skills Training (YST) or an attention control (AC).
    • Interventions were delivered individually during chemotherapy infusions, with recommended home practice.
    • Feasibility outcomes included accrual, retention, adherence, and data collection.

    Main Results:

    • 15 out of 52 identified patients enrolled, with 75% retention in the YST group and 71% in the AC group.
    • Participants demonstrated high adherence (97%) to in-person intervention sessions and completed all questionnaires.
    • Preliminary data on fatigue, sleep, quality of life, and biomarkers were collected.

    Conclusions:

    • A larger randomized controlled trial of Yoga Skills Training for colorectal cancer patients undergoing chemotherapy is feasible.
    • The study provides valuable insights into recruitment, retention, and data collection for future research.