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Published on: November 9, 2019
A quadruple cascade protocol for the one-pot synthesis of fully-substituted hexahydroisoindolinones from simple
Hong-Bo Zhang1, Yong-Chun Luo1, Xiu-Qin Hu1
1State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering Lanzhou University, Lanzhou 730000, P. R. China.
Abstract:
A new and efficient synthetic method to obtain fully-substituted hexahydroisoindolinones was developed by using bifunctional tertiary amine-thioureas as powerful catalysts. As far as we know, there is no efficient synthetic method developed toward fully-substituted hexahydroisoindolinones. The products were obtained in good yield and diastereoselectivity. The one-pot cascade quadruple protocol features readily available starting materials, simple manipulation, mild conditions and good atom economy.
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