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Updated: Mar 24, 2026

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
Published on: June 17, 2015
Advancing Risk Assessment through the Application of Systems Toxicology
John Michael Sauer1, André Kleensang2, Manuel C Peitsch3
1Predictive Safety Testing Consortium, Critical Path Institute, Tucson, AZ, USA.
Abstract:
Risk assessment is the process of quantifying the probability of a harmful effect to individuals or populations from human activities. Mechanistic approaches to risk assessment have been generally referred to as systems toxicology. Systems toxicology makes use of advanced analytical and computational tools to integrate classical toxicology and quantitative analysis of large networks of molecular and functional changes occurring across multiple levels of biological organization. Three presentations including two case studies involving both in vitro and in vivo approaches described the current state of systems toxicology and the potential for its future application in chemical risk assessment.
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