Related Experiment Video
Updated: Mar 24, 2026
Doppler Optical Coherence Tomography of Retinal Circulation
Published on: September 18, 2012
In vivo imaging of retinal hemodynamics with OCT angiography and Doppler OCT
Shenghai Huang1, Meixiao Shen1, Dexi Zhu2
1School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China; Co-first authors: they have contributed equally to the project.
Abstract:
Retinal hemodynamics is important for early diagnosis and precise monitoring in retinal vascular diseases. We propose a novel method for measuring absolute retinal blood flow in vivo using the combined techniques of optical coherence tomography (OCT) angiography and Doppler OCT. Doppler values can be corrected by Doppler angles extracted from OCT angiography images. A three-dimensional (3D) segmentation algorithm based on dynamic programming was developed to extract the 3D boundaries of optic disc vessels, and Doppler angles were calculated from 3D vessel geometry. The accuracy of blood flow from the Doppler OCT was validated using a flow phantom. The feasibility of the method was tested on a subject in vivo. The pulsatile retinal blood flow and the parameters for retinal hemodynamics were successfully obtained.
