[MRI-characteristics of epileptogenic supratentorial brain tumors in children]

V S Khalilov1, A A Kholin2, N A Medvedeva1

  • 1FGBUZ 'Tsentral'naja detskaja klinicheskaja bol'nitsa' FMBA Rossii, Moskva.

Abstract

Insights

Epileptogenic tumors, including dysembryoplastic neuroepithelial tumors (DNET), diffuse astrocytomas (DA), and gangliogliomas (GG), are common causes of symptomatic focal epilepsy. MRI analysis is crucial for identifying these tumors, especially in pharmacoresistant epilepsy cases.

Area of Science:

  • Neuro-oncology
  • Neuroradiology
  • Epileptology

Context:

  • Symptomatic epilepsy is frequently associated with brain tumors.
  • Supratentorial tumors are a significant cause of focal epilepsy.
  • Accurate tumor characterization on MRI is essential for diagnosis and treatment planning.

Purpose:

  • To analyze Magnetic Resonance Imaging (MRI) characteristics of epileptogenic tumors in patients with symptomatic epilepsy.
  • To identify the most common epileptogenic tumors and their typical MRI findings.
  • To evaluate the diagnostic utility of MRI in differentiating these tumors and guiding surgical intervention.

Summary:

  • Dysembryoplastic neuroepithelial tumors (DNET), diffuse astrocytomas (DA), and gangliogliomas (GG) were the most frequent epileptogenic tumors identified.
  • MRI revealed characteristic signal intensities and patterns, with DNET and GG often showing minimal mass effect and edema.
  • The study highlights the importance of recognizing subtle MRI signs to differentiate these tumors, which can mimic other pathologies.

Impact:

  • Findings aid in the early diagnosis and appropriate management of epilepsy secondary to brain tumors.
  • Improved understanding of MRI features can reduce misdiagnosis and guide surgical strategies for epileptogenic tumors.
  • This research underscores the necessity of considering epileptogenic tumors in the differential diagnosis of pharmacoresistant epilepsy.