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Updated: Mar 24, 2026

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
Published on: September 20, 2024
[MRI-characteristics of epileptogenic supratentorial brain tumors in children]
V S Khalilov1, A A Kholin2, N A Medvedeva1
1FGBUZ 'Tsentral'naja detskaja klinicheskaja bol'nitsa' FMBA Rossii, Moskva.
Objective:
To analyze MR-images in patients with symptomatic epilepsy associated with the brain tumor.
Material And Methods:
MRI results of 52 patients with symptomatic epilepsy operated for tumors of supratentorial localization were analyzed. The most epileptogenic tumors with atypical MRI signs and subtle clinical presentation were identified. All patients with tumors were operated using different methods of surgical intervention.
Results:
Dysembryoplastic neuroepithelial tumors (DNET), diffuse astrocytomas (DA) and gangliogliomas (GG) were the most frequent epileptogenic tumors. In all the cases of DNET and in 4 patients with GG, epileptic seizures were the first, and in 4 of 5 cases of DIO were the only clinical sign of tumor presence. In DNET, DA and GG, there was an iso- or hypointensive signal on T1 WI and a signal varying in intensity from moderate to hyperintense in T2 and FLAIR WI, while in cases with DNET and GG, no mass effect and perifocal edema was practically seen. The so-called «spume-like» (multicystic) structure was most clearly observed in FLAIR WI. No significant changes in the dimensions of the DNET and GG were identified. The combination of DNET with focal cortical dysplasia was noted in one case. In DA, it was difficult to distinguish the perifocal edema from tumorous tissue and normal brain tissues, and the growth potential of malformation was slow.
Conclusion:
Epileptogenic tumors can imitate the x-ray characteristics of each other, and mimicry to gangliogliomas, oligodendrogliomas and astrocytomas Gr I, II, and others. They are the most frequent causes of symptomatic focal epilepsy. The presence of these malformations is necessary to exclude first of all in all cases of pharmacoresistant epilepsy.
Insights
Epileptogenic tumors, including dysembryoplastic neuroepithelial tumors (DNET), diffuse astrocytomas (DA), and gangliogliomas (GG), are common causes of symptomatic focal epilepsy. MRI analysis is crucial for identifying these tumors, especially in pharmacoresistant epilepsy cases.
Area of Science:
- Neuro-oncology
- Neuroradiology
- Epileptology
Context:
- Symptomatic epilepsy is frequently associated with brain tumors.
- Supratentorial tumors are a significant cause of focal epilepsy.
- Accurate tumor characterization on MRI is essential for diagnosis and treatment planning.
Purpose:
- To analyze Magnetic Resonance Imaging (MRI) characteristics of epileptogenic tumors in patients with symptomatic epilepsy.
- To identify the most common epileptogenic tumors and their typical MRI findings.
- To evaluate the diagnostic utility of MRI in differentiating these tumors and guiding surgical intervention.
Summary:
- Dysembryoplastic neuroepithelial tumors (DNET), diffuse astrocytomas (DA), and gangliogliomas (GG) were the most frequent epileptogenic tumors identified.
- MRI revealed characteristic signal intensities and patterns, with DNET and GG often showing minimal mass effect and edema.
- The study highlights the importance of recognizing subtle MRI signs to differentiate these tumors, which can mimic other pathologies.
Impact:
- Findings aid in the early diagnosis and appropriate management of epilepsy secondary to brain tumors.
- Improved understanding of MRI features can reduce misdiagnosis and guide surgical strategies for epileptogenic tumors.
- This research underscores the necessity of considering epileptogenic tumors in the differential diagnosis of pharmacoresistant epilepsy.
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