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[Abnormal distribution of trace elements in keratoconic corneas]
S E Avetisov1, V R Mamikonyan1, I A Novikov1
1Research Institute of Eye Diseases, 11 A, B, Rossolimo St., Moscow, Russian Federation, 119021.
Keratoconus involves abnormal mineral metabolism, with trace element accumulation in the periphery and deficiency in the center. This suggests a link between impaired mineral balance and corneal ectasia development.
Area of Science:
- Ophthalmology
- Biochemistry
- Biophysics
Context:
- Corneal disorders' etiology and pathogenesis depend on human biochemistry and biophysics.
- Chemical mapping provides insights into corneal tissue composition.
Purpose:
- To perform chemical mapping of normal and keratoconic human corneas.
- To investigate the role of mineral metabolism in keratoconus.
Summary:
- Analytical chemistry methods, including X-ray fluorescence and energy-dispersive X-ray spectroscopy, were utilized.
- Analysis of normal and keratoconic corneas revealed abnormal iron, copper, and zinc accumulation in the Fleischer ring periphery of keratoconic samples.
- The central ectatic zone in keratoconus showed a deficiency in trace elements.
Impact:
- Findings suggest keratoconus pathogenesis involves impaired mineral metabolism.
- A physicochemical barrier formation in corneal tissues may contribute to keratectasia.
- This research opens avenues for understanding and potentially treating keratoconus through metabolic interventions.
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