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Pseudofracture: An Acute Peripheral Tissue Trauma Model
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Lupus and fractures.

Irene E M Bultink1, Willem F Lems

  • 1aDepartment of Rheumatology, Amsterdam Rheumatology and immunology Center, location VU University Medical Center bDepartment of Rheumatology, Amsterdam Rheumatology and immunology Center, location Reade, Amsterdam, The Netherlands.

Current Opinion in Rheumatology
|March 16, 2016
PubMed
Summary

Systemic lupus erythematosus (SLE) patients face increased fracture risks, particularly vertebral fractures, due to factors like glucocorticoid use. Reducing steroid therapy is crucial for managing these fractures and their significant health and economic impacts.

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Area of Science:

  • Rheumatology
  • Endocrinology
  • Bone Metabolism

Background:

  • Systemic lupus erythematosus (SLE) is associated with an elevated risk of fractures.
  • Osteoporosis and symptomatic fractures are increasingly recognized complications in SLE patients.

Purpose of the Study:

  • To review recent advancements in understanding fractures in SLE patients.
  • To highlight the clinical, scientific, and economic implications of these fractures.

Main Methods:

  • Literature review of recent studies on SLE and fractures.
  • Analysis of risk factors including age, disease duration, severity, and glucocorticoid use.
  • Examination of fracture prevalence, particularly vertebral fractures, and bone density.

Main Results:

  • Increased incidence of osteoporosis and symptomatic fractures in SLE.
  • Vertebral fractures are highly prevalent, often asymptomatic, and linked to reduced quality of life and increased mortality.
  • Fractures represent a significant economic burden, exacerbated by glucocorticoid use, which is common in SLE patients.

Conclusions:

  • SLE patients experience a higher rate of symptomatic and vertebral fractures with multifactorial causes.
  • Screening for vertebral fractures is essential due to their impact on patient outcomes.
  • Minimizing glucocorticoid therapy and utilizing steroid-sparing agents are vital for fracture prevention and management in SLE.