[Characteristics of immune response and inflammatory reaction in atherothrombotic stroke and myocardial infarction]

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Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
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Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Published on: February 12, 2016

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E V Konstantinova1, A G Kochetov1, N A Shostak1

  • 1Pirogov Russian National Research Medical University, Moscow.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|March 16, 2016
PubMed

Insights

Markers of immune response, inflammation, and apoptosis are elevated in myocardial infarction (MI) and atherothrombotic stroke (AS), indicating shared mechanisms in ischemic tissue damage. Specific correlations between these markers were identified in the acute phase.

Area of Science:

  • Biochemistry
  • Immunology
  • Pathophysiology

Context:

  • Myocardial infarction (MI) and atherothrombotic stroke (AS) are leading causes of mortality and morbidity.
  • Understanding the underlying mechanisms of ischemic tissue damage is crucial for developing effective treatments.

Purpose:

  • To investigate the correlations between markers of immune response, inflammation, and apoptosis in patients with MI and AS.
  • To characterize ischemic tissue damage by assessing these marker relationships.

Summary:

  • This study measured levels of matrix metalloproteinase-9 (MMP-9), immune complexes, soluble Fas-ligand, tumor necrosis factor alpha, and interleukin-10 in patients with MI and AS.
  • Flow cytometry was used to assess apoptosis, Toll-like receptors-4, and heat shock proteins.
  • Elevated levels of immune response, inflammation, and apoptosis markers were observed in the early stages of MI and AS.

Impact:

  • Identifies shared pathophysiological mechanisms in ischemic tissue damage in both MI and AS.
  • Highlights the specificity of marker relationships in the acute phase of these conditions.
  • Provides a novel approach to assessing the role of these parameters in acute myocardial ischemia and brain injury.
Abstract

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