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Updated: Mar 24, 2026
14:10
Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice
Published on: July 29, 2022
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[Abdominal sepsis and oxidative stress].
I N Pasechnik1, E I Skobelev1, V V Krylov1
1Educational and Research Medical Center of Presidential Administration of the Russian Federation, Moscow.
Khirurgiia
|March 16, 2016
Summary
Sepsis patients exhibit oxidative stress, with protein carbonyls correlating to multiple organ failure severity. Reduced protein sulfhydryl groups indicate a poor prognosis in abdominal sepsis.
Area of Science:
- Biochemistry
- Pathophysiology
- Medical Science
Context:
- Sepsis pathogenesis involves oxidative stress.
- Abdominal sepsis, particularly from peritonitis and pancreatitis, presents a significant clinical challenge.
- Assessing oxidative stress markers is crucial for understanding sepsis severity.
Purpose:
- To investigate the relationship between oxidative stress markers and the severity of multiple organ failure (MOF) in patients with abdominal sepsis.
- To evaluate lipid peroxidation (LPO) intensity and protein oxidative modification.
- To define the state of the anti-oxidant system (AOS) in sepsis patients.
Summary:
- This study analyzed 96 patients with abdominal sepsis, measuring malondialdehyde (MDA) for LPO, protein sulfhydryl (SH-groups) and carbonyls, and AOS enzyme activities.
- No correlation was found between MOF severity and MDA, SH-groups, or AOS enzyme levels.
- A positive correlation was observed between MOF severity and protein carbonyl content, indicating significant oxidative injury to proteins.
Impact:
- Protein carbonyl levels correlate with multiple organ failure severity in abdominal sepsis.
- Reduced SH-groups at sepsis diagnosis are an unfavorable prognostic factor.
- Findings highlight the role of protein oxidative damage in sepsis progression and outcomes.
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