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Variance in Biomarker Usefulness as Indicators for Carotid and Coronary Atherosclerosis

Michal Laufer Perl, Ariel Finkelstein, Miri Revivo

    The Israel Medical Association Journal : IMAJ
    |March 17, 2016
    PubMed

    Insights

    Different biomarkers indicate coronary artery disease (CAD) and carotid artery disease (CEAD), despite atherosclerosis being systemic. Identifying these specific biomarkers is crucial for targeted prevention and understanding disease mechanisms.

    Area of Science:

    • Cardiovascular Medicine
    • Biomarker Research
    • Atherosclerosis Studies

    Background:

    • Atherosclerosis is a systemic condition affecting multiple vascular beds.
    • The distinct roles of biomarkers in coronary artery disease (CAD) versus carotid artery disease (CEAD) require clarification.

    Purpose of the Study:

    • To investigate the association between various biomarkers and the presence/severity of both coronary and carotid artery disease.

    Main Methods:

    • 522 stable angina patients underwent simultaneous coronary angiography and carotid duplex ultrasound.
    • Biomarkers including lipids, hemoglobin A1c (HbA1c), white blood cell count, fibrinogen, and high-sensitivity C-reactive protein (hs-CRP) were measured.
    • Carotid intima-media thickness (CIMT) was assessed in patients without significant plaque.

    Main Results:

    • Higher hs-CRP levels correlated with significant carotid stenosis (P=0.001).
    • Elevated HbA1c (P<0.001) and low high-density lipoprotein (HDL) cholesterol (P<0.001) were associated with severe coronary artery disease.
    • No significant association was found between CIMT and any of the evaluated biomarkers.

    Conclusions:

    • Biomarkers show differential associations with coronary versus carotid artery disease.
    • Specific biomarker identification for each vascular territory is essential for effective prevention strategies.
    • Understanding these distinct associations may elucidate underlying pathophysiological mechanisms.
    Abstract

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