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Updated: Mar 24, 2026

Isolation of Primary Human Proximal Tubule Epithelial Cells and Their Use in Creating a Microphysiological Model of the Renal Proximal Tubule
07:06

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Drug Transporter Function--Implications in CKD.

Michael H Schwenk1, Amy Barton Pai1

  • 1Columbia University, New York, NY; and Albany College of Pharmacy and Health Sciences, Albany, NY.

Advances in Chronic Kidney Disease
|March 17, 2016
PubMed
Summary
This summary is machine-generated.

Genetic variations in drug transporters influence how the body processes medications. Understanding these genetic differences, particularly in kidney disease patients, is crucial for personalized medicine and improved drug safety.

Keywords:
ATP-binding cassette transportersDrug transportersOrganic anion transportersPharmacogenomics

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Area of Science:

  • Pharmacogenomics
  • Drug Metabolism and Transport

Background:

  • Drug transporters, including efflux and influx types, significantly impact drug pharmacokinetics.
  • Genetic variations (polymorphisms) in transporter genes are increasingly recognized.
  • ATP-binding cassette (ABC) and solute carrier (SLC) superfamilies encompass numerous drug transporter genes.

Purpose of the Study:

  • To explore the role of genetic variants in drug transporter genes.
  • To investigate the association between single-nucleotide polymorphisms (SNPs) and transporter function/drug exposure.
  • To highlight the potential impact of transporter genetic variations on clinical outcomes, especially in chronic kidney disease (CKD).

Main Methods:

  • Identification of genetic variants within major drug transporter superfamilies (ABC and SLC).
  • Analysis of associations between identified single-nucleotide polymorphisms (SNPs) and changes in protein expression, functionality, and drug exposure.
  • Review of preliminary data regarding transporter function in patients with CKD.

Main Results:

  • Numerous polymorphisms have been identified in genes encoding ABC and SLC transporters.
  • Many SNPs are linked to altered transporter expression, function, and drug exposure levels.
  • Limited data currently exist for most SNPs regarding their impact on clinical endpoints.

Conclusions:

  • Genetic variations in drug transporters are a key area in pharmacogenomics.
  • Further research is needed to translate the functional significance of these polymorphisms into clinical practice.
  • Understanding transporter genetic variations may improve drug efficacy and safety, particularly in patient populations like those with CKD.