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Chronic obstructive pulmonary disease is not a risk factor for polyneuropathy: A prospective controlled study
Nora A Visser1, Nicolette C Notermans1, Ferdinand Teding van Berkhout2
11 Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Chronic Respiratory Disease
|March 17, 2016
Summary
Chronic obstructive pulmonary disease (COPD) is not a risk factor for cryptogenic axonal polyneuropathy. This study found no increased prevalence of COPD in patients with polyneuropathy, suggesting no direct association.
Area of Science:
- Neurology
- Pulmonology
- Epidemiology
Background:
- Polyneuropathy is a potential extrapulmonary manifestation of chronic obstructive pulmonary disease (COPD).
- An increased prevalence of COPD would be expected in patients diagnosed with cryptogenic axonal polyneuropathy if it were a complication.
Purpose of the Study:
- To investigate the association between chronic obstructive pulmonary disease (COPD) and cryptogenic axonal polyneuropathy.
- To determine if COPD is a risk factor for developing polyneuropathy.
Main Methods:
- A prospective case-control study was conducted.
- 345 patients with cryptogenic axonal polyneuropathy and 465 controls were included.
- COPD diagnosis was assessed via questionnaire and physician verification, with severity classified by Global Initiative for Chronic Obstructive Lung Disease criteria.
Main Results:
- The prevalence of COPD was similar in both the polyneuropathy and control groups (15/345 vs. 12/465).
- The odds ratio for COPD in polyneuropathy patients was 1.7 (95% CI [0.8-3.7]), which was not statistically significant.
- Adjusting for confounders did not alter the results (adjusted OR 1.7, 95% CI 0.7-4.1).
- COPD severity was comparable between the groups.
Conclusions:
- This study does not support the hypothesis that chronic obstructive pulmonary disease (COPD) is a risk factor for cryptogenic axonal polyneuropathy.
- There is no significant association found between COPD and the development of polyneuropathy.
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