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A momentary biomarker for depressive mood.

Jinhyuk Kim1,2, Toru Nakamura1, Yoshiharu Yamamoto3

  • 1Graduate School of Education, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

In Silico Pharmacology
|March 17, 2016
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Summary

Physical activity shows promise as a momentary biomarker for psychiatric disorders, especially for monitoring depressive mood dynamics. This biobehavioral marker could enable objective tracking of illness progression and treatment response.

Keywords:
Depressive moodEcological momentary assessmentMajor depressive disordersPhysical activityPsychobehavioral biomarker

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Area of Science:

  • Psychiatry and Behavioral Science
  • Biomarker Discovery
  • Digital Health

Background:

  • Current biomarkers for psychiatric disorders lack the ability to capture dynamic changes during illness progression or treatment.
  • Objective monitoring of fluctuating pathological states requires novel, momentary biomarkers.
  • Ecological Momentary Assessment (EMA) shows potential for assessing daily clinical conditions and symptoms.

Purpose of the Study:

  • To introduce physical activity as a candidate biobehavioral biomarker for psychiatric disorders.
  • To explore the potential of physical activity as a momentary biomarker for depressive mood.
  • To discuss the application of continuous physical activity monitoring in understanding depressive disorder pathogenesis and treatment.

Main Methods:

  • Review of existing literature on biomarkers in psychiatry.
  • Exploration of ecological momentary assessment (EMA) and its validation studies.
  • Introduction of physical activity as a novel biobehavioral marker.

Main Results:

  • Physical activity is proposed as a promising momentary biomarker for psychiatric disorders.
  • Evidence suggests physical activity can objectively reflect momentary symptoms of depressive mood.
  • Continuous monitoring of physical activity may aid in tracking disease progression and treatment efficacy.

Conclusions:

  • Physical activity represents a viable candidate for a momentary biobehavioral biomarker in psychiatry.
  • Objective, continuous monitoring of physical activity can provide insights into the dynamic nature of psychiatric disorders, particularly depression.
  • This approach has potential applications in both human clinical studies and pharmacological animal research.