Multiscale entropy identifies differences in complexity in postural control in women with multiple sclerosis.

Area of Science:

• Neuroscience
• Biomechanics
• Human Physiology

Background:

• Reduced center-of-pressure (COP) complexity is linked to decreased adaptability in aging and disease.
• Postural control deficits are common in Multiple Sclerosis (MS), affecting daily function.
• Understanding COP complexity in MS can reveal underlying mechanisms of postural instability.

Purpose of the Study:

• To compare COP complexity between individuals with MS and healthy controls.
• To investigate the effect of limited vision on COP complexity in MS.
• To examine the relationship between COP complexity and MS disease severity, fatigue, and sensory function.

Main Methods:

• Assessed center of pressure (COP) complexity using the complexity index (CI).
• Compared COP complexity during quiet standing and maximal lean conditions.
• Evaluated the impact of normal versus limited vision on postural control.
• Correlated COP complexity with clinical measures including disease severity and fatigue.

Main Results:

• Individuals with MS demonstrated significantly lower COP complexity (CI) in both anterior-posterior (AP) and medio-lateral (ML) directions compared to controls.
• Reduced COP complexity was observed during maximal lean tasks and under limited vision conditions.
• Lower COP complexity in the AP direction was significantly associated with decreased cutaneous sensitivity in the MS group.

Conclusions:

• Multiple Sclerosis is associated with diminished COP complexity, indicating impaired postural adaptability.
• Cutaneous sensitivity plays a crucial role in maintaining COP complexity and postural control in MS.
• These findings suggest somatosensory deficits contribute significantly to postural instability in individuals with MS.