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Published on: July 6, 2013
Association of cytomegalovirus infection with hypertension risk: a meta-analysis
Jing Hui1, Yuan-Yuan Qu1,2, Na Tang1
1Department of Pathophysiology/Key Laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi, China.
Background:
Information regarding association between cytomegalovirus (CMV) infection and essential hypertension (EH) risk is not consistent across studies. Therefore, we conducted a meta-analysis to investigate the association in detail.
Methods:
We comprehensively searched the published literature from the PubMed and Embase databases for any study analyzing the association between CMV and EH risk. A random-effects model was used to calculate the pooled odds ratio (OR) with 95 % confidence interval (CI).
Results:
Three studies involving 9657 patients were included in the meta-analysis, and the results showed a significantly increased risk of EH in patients with CMV infection. Overall, 79.3 % of the hypertension patients were CMV-positive, which was significantly higher than the percentage for controls (OR = 1.39, 95 % CI = 0.95-2.05, P = 0.017). There was significant heterogeneity among the studies included (I(2) = 70.5 %). The funnel plot and Egger's test also indicated no publication bias.
Conclusions:
The results showed a significant association between CMV and EH, which indicates that CMV infection is a possible cause of EH.
