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Electroactive Polymer Nanoparticles Exhibiting Photothermal Properties
Published on: January 8, 2016
Single-step synthesis of heparin-doped polypyrrole nanoparticles for delivery of angiogenic factor
Gordon M Xiong1, Yi Zhen Yap1, Cleo Choong1,2
1School of Materials Science & Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798 Singapore.
Aim:
To perform one-pot synthesis of heparin-immobilized polypyrrole (PPy) nanoparticles and evaluate the use of these nanoparticles for the delivery of VEGF.
Materials & Methods:
Heparin-stabilized synthesis of PPy nanoparticles was performed via oxidative polymerization. VEGF-bound PPy-heparin nanoparticles were delivered to endothelial cells and bioactivity of VEGF was assessed by Matrigel tube formation.
Results:
Size-controllable synthesis of heparin-doped PPy nanoparticles was achieved, and heparin promoted the conjugation of VEGF. Angiogenic activity of the VEGF-conjugated PPy nanoparticles was verified.
Conclusion:
Heparin-doped PPy nanoparticles can be synthesized using one-pot reaction and provide a delivery platform by which VEGF can be conjugated onto.
