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Updated: Mar 24, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Evidence-Based Practice: What's New Is Old.
1Associate Professor, Saint Xavier University Florczak@sxu.edu.
Evidence-based practice evolved from research utilization. Newer fields like implementation science also stem from this foundational process, highlighting a continuous link in scientific advancement.
Area of Science:
- Healthcare research
- Scientific methodology
- Knowledge translation
Background:
- Evidence-based practice (EBP) is a cornerstone of modern healthcare.
- The origins and evolution of EBP are often discussed in relation to research findings.
- Understanding the historical development of EBP is crucial for its effective implementation.
Purpose of the Study:
- To demonstrate that evidence-based practice (EBP) originated from the process of research utilization.
- To explore the direct linkage between research utilization and EBP.
- To show that implementation science and de-implementation science also have roots in research utilization.
Main Methods:
- Conceptual analysis of the historical development of research utilization.
- Literature review examining the relationship between research utilization and EBP.
- Discussion of the foundational role of research utilization in newer scientific fields.
Main Results:
- Evidence-based practice (EBP) directly evolved from the principles and practices of research utilization.
- A strong, historical connection exists between the concepts of research utilization and EBP.
- Implementation science and de-implementation science share common origins with research utilization.
Conclusions:
- The historical trajectory shows EBP emerging from research utilization.
- Recognizing these roots can inform current and future knowledge translation efforts.
- Research utilization remains a fundamental concept underpinning various scientific implementation strategies.
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