Macular Amyloidosis and Epstein-Barr Virus

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Yalda Nahidi1, Naser Tayyebi Meibodi1, Zahra Meshkat2

  • 1Skin Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9176699199, Iran.

Dermatology Research and Practice
|March 17, 2016
PubMed

Insights

Epstein-Barr virus (EBV) DNA was not found to be significantly present in macular amyloidosis skin lesions. This study concludes that EBV does not play a role in the pathogenesis of this skin condition.

Area of Science:

  • Dermatology
  • Virology
  • Pathogenesis

Background:

  • Amyloidosis involves extracellular precipitation of eosinophilic hyaline material.
  • Macular amyloidosis is a skin-limited form with proposed pathogenic factors.
  • Epstein-Barr virus (EBV) DNA detection in lesions suggested a potential role in pathogenesis.

Purpose of the Study:

  • To investigate the presence of Epstein-Barr virus (EBV) DNA in macular amyloidosis skin lesions.
  • To compare EBV DNA detection rates between patients with macular amyloidosis and a healthy control group.

Main Methods:

  • Polymerase Chain Reaction (PCR) was used for EBV DNA detection.
  • Analyzed 30 skin samples from patients with macular amyloidosis.
  • Compared with 31 healthy skin samples from the margin of melanocytic nevi.

Main Results:

  • EBV DNA (BLLF1 gene) was detected in 8 cases (3.8%) and 15 controls (23.8%).
  • No statistically significant difference in EBV DNA presence was observed between the groups (P = 0.08).

Conclusions:

  • The study found no significant association between Epstein-Barr virus and macular amyloidosis.
  • EBV is unlikely to be involved in the pathogenesis of macular amyloidosis.

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