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Updated: Mar 24, 2026

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research
Published on: October 20, 2023
Diagnosis and management of patients with asymptomatic severe aortic stenosis
Minako Katayama1, Hari P Chaliki1
1Minako Katayama, Hari P Chaliki, Division of Cardiovascular Diseases, Mayo Clinic, Scottsdale, AZ 85259, United States.
Abstract:
Aortic stenosis (AS) is a disease that progresses slowly for years without symptoms, so patients need to be carefully managed with appropriate follow up and referred for aortic valve replacement in a timely manner. Development of symptoms is a clear indication for aortic valve intervention in patients with severe AS. The decision for early surgery in patients with asymptomatic severe AS is more complex. In this review, we discuss how to identify high-risk patients with asymptomatic severe AS who may benefit from early surgery.
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