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Updated: Mar 24, 2026

Measurement of Natural Killer Cell-Mediated Cytotoxicity and Migration in the Context of Hepatic Tumor Cells
Published on: February 22, 2020
A role for pre-mNK cells in tumor progression
Carolyn Rosinsky1, Paul Andrew Antony2
1Program in Molecular Medicine, University of Maryland School of Medicine, Baltimore, MD 21201 USA ; Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201 USA.
Abstract:
The innate and adaptive immune systems have evolved together to fight infection and cancerous tissues. The innate immune system emerges first with the adaptive immune system following, both ostensibly being bridged by dendritic cells (DC). Recently cells have emerged that possess characteristics of both innate and adaptive immune cell qualities, termed interferon-producing killer dendritic cells (IKDCs). These cells have an indistinct origin that is not well understood. They appear to have more NK cell attributes than DC but purportedly can regulate the immune system similar to immunoregulatory NK cells. Because of this, they have been renamed pre-mNK cells (pre-mature NK cells). We argue in this commentary that pre-mNK cells may contribute to cancer recurrence.
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