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Related Experiment Video

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Arterial input function placement effect on computed tomography lung perfusion maps.

Laura Jimenez-Juan1, Hatem Mehrez1, Chris Dey1

  • 11 Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada ; 2 Department of Medical Imaging, Sunnybrook Health Science Centre, Toronto, Ontario, Canada ; 3 Toshiba Medical Systems, Markham, Ontario, Canada ; 4 Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada ; 5 Department of Biology, University of Toronto, Toronto, Ontario, Canada.

Quantitative Imaging in Medicine and Surgery
|March 17, 2016
PubMed
Summary
This summary is machine-generated.

The location of the arterial input function (AIF) in the pulmonary trunk, right, or left main arteries does not impact the accuracy of pulmonary blood flow (PBF) maps generated using dynamic perfusion computed tomography (DPCT). This finding simplifies DPCT analysis for lung imaging.

Keywords:
Perfusion imagingcomputed tomography (CT)pulmonary artery

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Area of Science:

  • Medical Imaging
  • Radiology
  • Cardiopulmonary Imaging

Background:

  • Arterial input function (AIF) location is a key variable in dynamic perfusion computed tomography (DPCT).
  • The influence of AIF location on lung DPCT accuracy remains unexplored.
  • Investigating AIF placement is crucial for standardizing DPCT protocols.

Purpose of the Study:

  • To evaluate if AIF location within central pulmonary arteries affects lung DPCT map accuracy.
  • To determine the optimal AIF placement for reliable pulmonary blood flow (PBF) quantification.
  • To assess the impact of AIF positioning on perfusion defect detection in lung DPCT.

Main Methods:

  • 54 lung DPCT scans in pigs with varying contrast media administration.
  • Generated PBF maps using first-pass kinetics with AIF in main pulmonary trunk (PT), right main (RM), and left main (LM) arteries.
  • Compared time density curves (TDCs) and PBF maps using linear regression, Spearman correlation, ANOVA, and qualitative radiologist assessment.

Main Results:

  • TDCs from RM and LM showed high correlation with PT (median regression 1.01, Spearman 0.88).
  • ANOVA revealed no statistically significant differences in PBF values across AIF locations (P>0.05).
  • Qualitative assessment indicated identical or comparable perfusion maps regardless of AIF site, with no significant difference in perfusion defects.

Conclusions:

  • Accurate PBF perfusion maps are achievable with AIF placed in the PT, RM, or LM pulmonary arteries.
  • AIF location within these central pulmonary arteries does not compromise the diagnostic quality of lung DPCT.
  • These findings support flexibility in AIF selection for lung DPCT analysis.