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Serum Klotho Levels in Trained Athletes.
Elmira Mostafidi1, Akbar Moeen2, Hamid Nasri3
1Department of Pathology, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, IR Iran; Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran.
Trained athletes exhibit significantly higher circulating Klotho levels, an anti-aging protein. This finding suggests regular aerobic exercise may boost Klotho, potentially contributing to exercise-related anti-aging benefits.
Area of Science:
- Gerontology and Exercise Physiology
- Biochemistry of Aging
- Kidney Function and Protein Secretion
Background:
- Klotho is a key anti-aging protein primarily produced by the kidneys.
- Understanding factors influencing Klotho levels is crucial for aging research.
- Exercise is known to impact various physiological markers.
Purpose of the Study:
- To compare serum Klotho levels between trained athletes and healthy non-athletes.
- To investigate the potential relationship between exercise and circulating Klotho.
- To explore Klotho as a mediator of exercise-induced anti-aging effects.
Main Methods:
- Serum Klotho concentrations were measured in 30 trained football players.
- Measurements were taken the morning after evening exercise training.
- A control group of healthy non-athletes was included for comparison.
Main Results:
- Plasma free Klotho concentration was significantly higher in athletes (3.375 ± 1.48 ng/mL) versus non-athletes (1.39 ± 0.43 ng/mL).
- Statistical significance was observed (P < 0.05).
- No significant differences were found in serum cholesterol, triglycerides, calcium, or phosphorus levels between groups.
Conclusions:
- Regular aerobic exercise appears to elevate plasma Klotho levels.
- Increased Klotho may be a mechanism behind the anti-aging effects of exercise.
- This study highlights a potential link between physical activity and longevity markers.
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