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Published on: September 26, 2013
The Role of γδ T Cells in Systemic Lupus Erythematosus
Meng Wu1, Jinhua Yang1, Xiaofeng Li1
1Department of Rheumatology, The Second Hospital of Shanxi Medical University, Shanxi, Taiyuan 030001, China.
Abstract:
Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the overproduction of autoantibodies against an array of nuclear and cytoplasmic antigens and affects multiple organs, such as the skin, joints, kidneys, and neuronal tissues. T cells have been recognized as important players in the development of SLE due to their functions in cytokine secretion, antigen presentation, and supporting B cells for antibody production. γδ T cells are a minor population of T cells that play important roles in infection and tumor-associated disease. In recent years, the role of γδ T cells in autoimmune diseases has been investigated. In this review, we discussed the role of γδ T cells in the pathogenesis of SLE.
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