The Association between VEGFR Gene Polymorphisms and Stroke: A Meta-Analysis

Area of Science:

• Genetics
• Neurology
• Molecular Biology

Background:

• Conflicting results exist regarding the association between VEGF receptor gene polymorphisms and stroke risk.
• A comprehensive meta-analysis is needed to clarify these relationships.

Purpose of the Study:

• To investigate the association between specific VEGF receptor gene polymorphisms (-604T>C, +1192C>T, and +1719A>T) and the risk of stroke.
• To provide a clearer understanding of the genetic factors influencing stroke susceptibility.

Main Methods:

• Systematic literature search of PubMed, Embase, CNKI, Wanfang, and VIP databases.
• Inclusion of 5 case-control studies with a total of 2904 stroke cases and 2824 controls.
• Calculation of pooled odds ratios (OR) with 95% confidence intervals (CI) under dominant and recessive genetic models.

Main Results:

• The -604T>C polymorphism was not significantly associated with stroke risk under either genetic model (P > 0.05).
• The +1192C>T polymorphism showed a significant association with stroke risk under the recessive model (OR = 1.611, P = 0.048).
• The +1719A>T polymorphism was significantly associated with stroke risk under the recessive model (OR = 1.139, P = 0.027).

Conclusions:

• VEGF receptor gene polymorphisms +1192C>T and +1719A>T may be associated with an increased risk of stroke.
• -604T>C polymorphism is unlikely to be a significant risk factor for stroke.
• Further research is warranted to confirm these findings and explore underlying mechanisms.