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Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...

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C1q/TNF-Related Protein-9 (CTRP9) Levels Are Associated With Obesity and Decrease Following Weight Loss Surgery.

Risa M Wolf¹, Kimberley E Steele¹, Leigh A Peterson¹

¹Departments of Pediatrics (R.M.W.), Surgery (K.E.S., L.A.P., M.A.S., T.H.M.), and Physiology (X.Z., G.W.W.), and Center for Metabolism and Obesity Research (R.M.W., G.W.W.), The Johns Hopkins University School of Medicine, Baltimore, Maryland; Lieber Institute for Brain Development (A.E.J.), Johns Hopkins Medical Campus, Baltimore, Maryland; and Departments of Mental Health (A.E.J.) and Biostatistics (A.E.J.), Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

The Journal of Clinical Endocrinology and Metabolism

|March 17, 2016

Summary

This summary is machine-generated.

Levels of C1q/TNF-related protein-9 (CTRP9) are elevated in obesity and decrease after weight loss surgery. This suggests CTRP9 may play a compensatory role in obesity and is reduced by bariatric procedures.

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Area of Science:

Endocrinology
Metabolic Research
Cardiovascular Science

Background:

C1q/TNF-related protein-9 (CTRP9) is an adipokine with known metabolic and cardiovascular benefits.
Circulating CTRP9 levels are altered in patients with cardiovascular disease and diabetes.
The impact of obesity and bariatric surgery on CTRP9 concentrations remains largely unknown.

Purpose of the Study:

To compare CTRP9 levels between obese and lean individuals.
To investigate the effect of bariatric surgery on circulating CTRP9 levels in morbidly obese patients.

Main Methods:

Cross-sectional study involving 59 obese bariatric patients and 62 lean controls.
Cohort study with 21 obese patients analyzed at 3 and 6 months post-bariatric surgery (Roux-en-Y gastric bypass, vertical sleeve gastrectomy).
Fasting serum analyzed for CTRP9, insulin, adiponectin, leptin, glucose, HbA1c, and lipid profiles using ELISA and standard laboratory methods.

Main Results:

Serum CTRP9 was significantly higher in obese individuals compared to lean controls, independent of age, gender, and ethnicity.
Following bariatric surgery, significant weight loss was observed at 3 and 6 months.
Post-surgery, CTRP9, HbA1c, and leptin levels decreased, while adiponectin levels increased.

Conclusions:

CTRP9 levels are elevated in obesity and decrease significantly after bariatric surgery.
CTRP9 may have a compensatory role in obesity, similar to insulin.
Weight loss surgery down-regulates CTRP9, suggesting its involvement in metabolic regulation post-surgery.