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The Angiotensin Converting Enzyme Insertion/Deletion Polymorphism Modifies Exercise-Induced Muscle Metabolism

David Vaughan1, Michael Brogioli1,2, Thomas Maier1,2

  • 1Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Manchester, United Kingdom.

Plos One
|March 17, 2016
PubMed
Summary

The angiotensin-converting enzyme (ACE) DD genotype is linked to reduced aerobic capacity and impaired glucose metabolism in skeletal muscle, potentially leading to a pre-diabetic state during exercise. This is associated with lower muscle capillarisation and altered mitochondrial function.

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