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Related Concept Videos

Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

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Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Aminoglycosides constitute a highly potent class of bactericidal antibiotics that exert their antimicrobial effects by targeting the bacterial ribosome, specifically disrupting protein synthesis. These polycationic molecules consist of amino-modified sugars linked via glycosidic bonds to an aminocyclitol core such as 2-deoxystreptamine or streptamine. Their strong positive charges facilitate tight binding to the negatively charged phosphate backbone of ribosomal RNA (rRNA), primarily at the 16S...
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Related Experiment Video

Updated: Mar 24, 2026

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
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Tigecycline: Alone or in combination?

Yun Cai1, Nan Bai1, Xu Liu1

  • 1a Center of Medicine Clinical Research, Translational Medical Center , PLA General Hospital , Beijing , PR China.

Infectious Diseases (London, England)
|March 17, 2016
PubMed
Summary
This summary is machine-generated.

Tigecycline combination therapy shows promise against multidrug-resistant pathogens, but more research is needed. When severe infections leave no other options, combining tigecycline with other drugs based on susceptibility testing is recommended.

Keywords:
Tigecylinecombinationmultidrug resistant

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Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Microbiology

Background:

  • Tigecycline is a broad-spectrum antibiotic effective against multidrug-resistant (MDR) pathogens.
  • Clinical reports suggest tigecycline monotherapy may be insufficient for severe infections.
  • Combination therapy offers advantages like broad coverage and synergistic effects against MDR bacteria.

Purpose of the Study:

  • To review in vitro and in vivo studies on tigecycline combination therapy for MDR pathogens.
  • To assess the efficacy and outcomes of tigecycline in combination regimens.

Main Methods:

  • Systematic literature search using terms 'tigecycline', 'GAR-936', 'glycylcycline', and 'combination'.
  • Database searched: PubMed (January 1993-August 2015).
  • Inclusion of in vitro, in vivo, and case report studies.

Main Results:

  • Colistin-tigecycline was the most frequently studied combination with promising efficacy.
  • Synergistic effects were observed with tigecycline combined with sulbactam, carbapenems, or rifampicin.
  • Most data originated from in vitro and animal studies; favorable outcomes were noted in some case reports.

Conclusions:

  • Combination therapy with tigecycline may be a viable option for severe infections when monotherapy fails.
  • Drug selection should be guided by infection status and in vitro susceptibility testing.
  • Further well-designed clinical trials are essential to compare tigecycline combination therapy with monotherapy.