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Related Concept Videos

Mucosal Barrier of the Stomach01:25

Mucosal Barrier of the Stomach

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The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
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Related Experiment Video

Updated: Mar 24, 2026

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis
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Mucosal Healing - How Deep Is Enough?

Marietta Iacucci1, Subrata Ghosh

  • 1Division of Gastroenterology, Snyder Institute of Chronic Inflammation, University of Calgary, Calgary, Alta., Canada.

Digestive Diseases (Basel, Switzerland)
|March 17, 2016
PubMed
Summary
This summary is machine-generated.

Mucosal healing is a key goal in inflammatory bowel disease (IBD) treatment, but its definition and assessment require further validation and standardization for accurate patient outcomes.

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Area of Science:

  • Gastroenterology and Hepatology
  • Inflammatory Bowel Disease Research

Background:

  • Mucosal healing is a critical treatment endpoint in inflammatory bowel disease (IBD), influencing clinical trials and patient care.
  • Current definitions and scoring systems for mucosal healing are evolving and require further validation.
  • Inter-observer variability in endoscopic assessment and the persistence of subclinical inflammation pose challenges.

Purpose of the Study:

  • To review the evolving definition and assessment of mucosal healing in IBD.
  • To discuss the role of novel endoscopic techniques and histological correlation.
  • To examine the utility and limitations of surrogate markers like fecal calprotectin.

Main Methods:

  • Literature review and synthesis of current research on mucosal healing in IBD.
  • Analysis of evolving definitions, scoring systems, and endoscopic techniques.
  • Discussion of surrogate markers and their correlation with mucosal healing.

Main Results:

  • Mucosal healing is increasingly used as a therapeutic target in IBD, but its precise definition remains debated.
  • Advanced endoscopic methods reveal persistent subtle inflammation even when conventional criteria for healing are met.
  • The relationship between endoscopic, histological, and fecal calprotectin markers of healing is complex and requires further investigation.

Conclusions:

  • Standardization of mucosal healing definitions and assessment is crucial for reliable clinical trial outcomes and patient management in IBD.
  • Further research is needed to clarify the role of histological healing and surrogate markers in defining true mucosal healing.
  • Addressing persistent subclinical inflammation and visceral hypersensitivity is essential for comprehensive IBD treatment.